COMBINED ROLE OF COMP, TGF-Β, AND CXCL10 BIOMARKERS IN PREDICTING EARLY TISSUE DESTRUCTION IN AUTOIMMUNE DISEASES
Keywords:
rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, autoimmune vasculitides, and inflammatory joint diseasesAbstract
Autoimmune diseases represent a heterogeneous group of chronic disorders characterized by dysregulated immune responses against self-antigens, leading to persistent inflammation, progressive tissue damage, and functional impairment. Conditions such as rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, autoimmune vasculitides, and inflammatory joint diseases impose a substantial clinical and socioeconomic burden worldwide. Despite advances in immunomodulatory therapies, many patients continue to experience irreversible structural damage, highlighting the need for earlier detection of destructive processes before overt clinical deterioration occurs.
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